Best Over-the-Counter Medicines for COVID-19 in 2026

If you have COVID‑19, it’s normal to reach for over‑the‑counter (OTC) medications to relieve symptoms like fever, headache, cough or congestion. However, not all medicines are appropriate for everyone, and some treatments should be avoided unless directed by a healthcare professional.

Which over‑the‑counter medications are safe for COVID‑19?

For most adults with mild to moderate COVID-19 symptoms, common over‑the‑counter medicines traditionally used for colds and flu may provide relief and can be used safely when taken as directed. 

These include: 

• Fever reducers
• Pain relievers
• Cough suppressants
• Decongestants

We advise you to avoid unproven treatments or antibiotics unless your doctor prescribes them. Antibiotics treat bacteria, not viruses like COVID-19. Also, be careful with medications that might react with antiviral prescriptions.

Always talk to your doctor or healthcare provider about over-the-counter medications for COVID if you have a weak immune system, take daily prescription medications, or have specific health concerns. We recommend you stick to the care plan your medical team provides.

Which medicine should you avoid if you have COVID‑19?

Research and clinical experience help us understand what works best. For most people with mild to moderate illness, we recommend avoiding:

• "Miracle cures": Avoid products marketed as cures without scientific proof.
• Unnecessary antibiotics: These do not treat viral infections such as COVID-19. Only use them if a clinician diagnoses a bacterial infection.
• Drugs that cause interactions: Some OTC medicines and herbal supplements react poorly with prescription drugs like blood pressure medication or antivirals like Paxlovid. Always review your full list of medicines with a doctor or pharmacist.

What are the current symptoms of COVID-19?

COVID-19 symptoms range from mild to severe. They often look like a cold or the flu. People with chronic conditions or weakened immune systems face a higher risk for serious illness, such as pneumonia or bronchitis.

Symptoms usually appear two to 14 days after you are exposed. You might experience:

• Fever or chills
• Cough
• Shortness of breath or difficulty breathing
• Fatigue
• Muscle or body aches
• Headache
• New loss of taste or smell
• Congestion or runny nose
• Nausea or vomiting
• Diarrhea

Check your symptoms with our symptom checker.

What is the best decongestant for COVID?

Decongestants help clear a stuffy nose. Effective over-the-counter options include:

• Guaifenesin (Mucinex)
• Pseudoephedrine (Sudafed)
• Dextromethorphan (Robitussin and Delsym)

Always read the label carefully to ensure you take the correct dose.

Which over-the-counter medicine helps reduce fever with COVID-19?

Acetaminophen (Tylenol) is commonly used to relieve fever and body aches. Use as directed and talk with your provider if you have liver disease or take multiple medications.

Can I use ibuprofen or naproxen for COVID-19 discomfort?

Yes, over-the-counter NSAIDs (non-steroidal anti-inflammatory drugs) like ibuprofen or naproxen may help pain and fever. If you have stomach ulcers or kidney issues, ask your doctor before using them.

What are the best home remedies for congestion?

Medicine isn't the only way to find relief. These simple home treatments can help you feel better:

• A humidifier
• Taking a long, hot shower (but not too hot)
• Using nasal saline spray
• Using Vick VapoRub on your chest
• Drinking a lot of fluids to help thin out your mucus
• At night, propping yourself up on pillows to make breathing easier.

What are self-care treatment options for COVID-19?

You should practice social distancing and stay inside your home. If you live with other people, try to avoid contact with them to avoid cross-contamination. If possible, use a separate bathroom. Get plenty of rest, stay hydrated, and take any medication recommended by your physician.

Also, it’s important for you to continue monitoring your symptoms. If your symptoms get worse, please contact your doctor or healthcare provider immediately. 

When should you contact your doctor for COVID?

Reach out to your care team if you:

• Take daily prescription medications
• Have chronic conditions like heart disease, diabetes or kidney disease
• Are pregnant or immunocompromised
• Feel unsure about which medicines are safe for you

If symptoms worsen or you develop signs of severe illness, seek immediate medical care.

When should you seek emergency medical care for COVID?

Go to the emergency room immediately if you experience:

• Trouble breathing
• Persistent pain or pressure in your chest
• New confusion
• Inability to wake up or stay awake
• Pale, gray or blue-colored skin, lips or nail beds

Your healthcare provider is your partner in health. They can confirm which over-the-counter medications are safe for your specific needs. If you have questions about COVID‑19 symptoms or medications, contact your doctor or healthcare provider or our on-call nurse hotline for personalized guidance.